abstract：:It has been difficult to examine the role of TGF-ß in post-natal tooth development due to perinatal lethality in many of the signaling deficient mouse models. To address the role of Tgfbr2 in postnatal tooth development, we generated a mouse in which Tgfbr2 was deleted in odontoblast- and bone-producing mesenchyme. Os...

journal_title：Developmental biology

authors： Wang Y,Cox MK,Coricor G,MacDougall M,Serra R

更新日期：2013-10-01 00:00:00

abstract：:The hallmark of the arthropods is their segmented body, although origin of segmentation, however, is unresolved. In order to shed light on the origin of segmentation we investigated orthologs of pair rule genes (PRGs) and segment polarity genes (SPGs) in a member of the closest related sister-group to the arthropods, ...

journal_title：Developmental biology

authors： Janssen R,Budd GE

更新日期：2013-10-01 00:00:00

abstract：:Actin dynamics are necessary at multiple steps in the formation of multinucleated muscle cells. BAR domain proteins can regulate actin dynamics in several cell types, but have been little studied in skeletal muscle. Here, we identify novel functions for the N-BAR domain protein, Bridging integrator 3 (Bin3), during my...

journal_title：Developmental biology

authors： Simionescu-Bankston A,Leoni G,Wang Y,Pham PP,Ramalingam A,DuHadaway JB,Faundez V,Nusrat A,Prendergast GC,Pavlath GK

更新日期：2013-10-01 00:00:00

abstract：:The adult fungiform taste papilla is a complex of specialized cell types residing in the stratified squamous tongue epithelium. This unique sensory organ includes taste buds, papilla epithelium and lateral walls that extend into underlying connective tissue to surround a core of lamina propria cells. Fungiform papilla...

journal_title：Developmental biology

authors： Liu HX,Ermilov A,Grachtchouk M,Li L,Gumucio DL,Dlugosz AA,Mistretta CM

更新日期：2013-10-01 00:00:00

abstract：:How natural variation in embryo size affects patterning of the Drosophila embryo dorsal-ventral (DV) axis is not known. Here we examined quantitatively the relationship between nuclear distribution of the Dorsal transcription factor, boundary positions for several target genes, and DV axis length. Data were obtained f...

journal_title：Developmental biology

authors： Garcia M,Nahmad M,Reeves GT,Stathopoulos A

更新日期：2013-09-01 00:00:00

abstract：:Congenital diseases caused by abnormal development of the cranial neural crest usually present craniofacial malformations and heart defects while the precise mechanism is not fully understood. Here, we show that the zebrafish eif3ba mutant caused by pseudo-typed retrovirus insertion exhibited a similar phenotype due t...

journal_title：Developmental biology

authors： Xia Z,Tong X,Liang F,Zhang Y,Kuok C,Zhang Y,Liu X,Zhu Z,Lin S,Zhang B

更新日期：2013-09-01 00:00:00

abstract：:The enteric nervous system (ENS) forms from the neural crest-derived precursors that colonize the bowel before differentiating into a network of neurons and glia that control intestinal function. Retinoids are essential for normal ENS development, but the role of retinoic acid (RA) metabolism in development remains in...

journal_title：Developmental biology

authors： Wright-Jin EC,Grider JR,Duester G,Heuckeroth RO

更新日期：2013-09-01 00:00:00

abstract：:Egg yolk phosvitin is one of the most highly phosphorylated extracellular matrix proteins known in nature with unique physico-chemical properties deemed to be critical during ex-vivo egg embryo development. We have utilized our unique live mouse calvarial bone organ culture models under conditions which dissociates th...

journal_title：Developmental biology

authors： Liu J,Czernick D,Lin SC,Alasmari A,Serge D,Salih E

更新日期：2013-09-01 00:00:00

abstract：:Urodele amphibians can regenerate their limbs. During limb regeneration, dermal fibroblasts are transformed into undifferentiated cells called blastema cells. These dermis-blastema cells show multipotency. Such so-called endogenous reprogramming of cell differentiation is one of the main targets of amphibian limb rege...

journal_title：Developmental biology

authors： Makanae A,Hirata A,Honjo Y,Mitogawa K,Satoh A

更新日期：2013-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are post-transcriptional regulators of growth and development in both plants and animals. Flowering is critical for the reproduction of angiosperms. Flower development entails the transition from vegetative growth to reproductive growth, floral organ initiation, and the development of floral organs....

journal_title：Developmental biology

authors： Luo Y,Guo Z,Li L

更新日期：2013-08-15 00:00:00

abstract：:Polycomb group (PcG) proteins are best known for their role in maintaining stable, mitotically heritable silencing of the homeotic (HOX) genes during development. In addition to loss of homeotic gene silencing, some PcG mutants also have small imaginal discs. These include mutations in E(z), Su(z)12, esc and escl, whi...

journal_title：Developmental biology

authors： Mason-Suares H,Tie F,Yan CM,Harte PJ

更新日期：2013-08-01 00:00:00

abstract：:Somatic gonadal niche cells control the survival, differentiation, and proliferation of germline stem cells. The establishment of this niche-stem cell relationship is critical, and yet the precursors to these two cell types are often born at a distance from one another. The simple Caenorhabditis elegans gonadal primor...

journal_title：Developmental biology

authors： Rohrschneider MR,Nance J

更新日期：2013-07-15 00:00:00

abstract：:The Drosophila ovarian germline stem cells (GSCs) constantly experience self-renewal and differentiation, ensuring the female fertility throughout life. The balance between GSC self-renewal and differentiation is exquisitely regulated by the stem cell niche, the stem cells themselves and systemic factors. Increasing e...

journal_title：Developmental biology

authors： Xuan T,Xin T,He J,Tan J,Gao Y,Feng S,He L,Zhao G,Li M

更新日期：2013-07-15 00:00:00

abstract：:In marine teleosts, the aqp1ab water channel plays a vital role in the development of the pelagic egg phenotype. However, the developmental control of aqp1ab activation during oogenesis remains to be established. Here, we report the isolation of the 5'-flanking region of the teleost gilthead seabream aqp1ab gene, in w...

journal_title：Developmental biology

authors： Zapater C,Chauvigné F,Tingaud-Sequeira A,Finn RN,Cerdà J

更新日期：2013-05-15 00:00:00

abstract：:In many non-mammalian vertebrates, adult dentitions result from cyclical rounds of tooth regeneration wherein simple unicuspid teeth are replaced by more complex forms. Therefore and by contrast to mammalian models, the numerical majority of vertebrate teeth develop shape during the process of replacement. Here, we ex...

journal_title：Developmental biology

authors： Fraser GJ,Bloomquist RF,Streelman JT

更新日期：2013-05-15 00:00:00

abstract：:Differentiation from a haploid round spermatid to a highly streamlined, motile sperm requires temporal and spatial regulation of the expression of numerous proteins. One form of regulation is the storage of translationally repressed mRNAs. In Drosophila spermatocytes, the transcription of many of these translationally...

journal_title：Developmental biology

authors： Barckmann B,Chen X,Kaiser S,Jayaramaiah-Raja S,Rathke C,Dottermusch-Heidel C,Fuller MT,Renkawitz-Pohl R

更新日期：2013-05-01 00:00:00

abstract：:Nanos is a translational regulator required for the survival and maintenance of primordial germ cells during embryogenesis. Three nanos homologs are present in the genome of the sea urchin Strongylocentrotus purpuratus (Sp), and each nanos mRNA accumulates specifically in the small micromere (sMic) lineage. We found t...

journal_title：Developmental biology

authors： Oulhen N,Yoshida T,Yajima M,Song JL,Sakuma T,Sakamoto N,Yamamoto T,Wessel GM

更新日期：2013-05-01 00:00:00

abstract：:Meckel-Gruber syndrome (MKS) is an embryonic lethal ciliopathy resulting from mutations in genes encoding proteins localising to the primary cilium. Mutations in the basal body protein MKS1 account for 7% of cases of MKS. The condition affects the development of multiple organs, including brain, kidney and skeleton. H...

journal_title：Developmental biology

authors： Wheway G,Abdelhamed Z,Natarajan S,Toomes C,Inglehearn C,Johnson CA

更新日期：2013-05-01 00:00:00

abstract：:Notch signaling has a fundamental role in stem cell maintenance and in cell fate choice in the intestine of different species. Canonically, Notch signaling represses the expression of transcription factors of the achaete-scute like (ASCL) or atonal related protein (ARP) families. Identifying the ARP/ASCL genes express...

journal_title：Developmental biology

authors： Flasse LC,Stern DG,Pirson JL,Manfroid I,Peers B,Voz ML

更新日期：2013-04-15 00:00:00

abstract：:The vertebrate intestinal epithelium is renewed continuously from stem cells at the base of the crypt in mammals or base of the fold in fish over the life of the organism. As stem cells divide, newly formed epithelial cells make an initial choice between a secretory or enterocyte fate. This choice has previously been ...

journal_title：Developmental biology

authors： Roach G,Heath Wallace R,Cameron A,Emrah Ozel R,Hongay CF,Baral R,Andreescu S,Wallace KN

更新日期：2013-04-15 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer. This emerging importance of lncRNAs, along with rec...

journal_title：Developmental biology

authors： Kraus P,Sivakamasundari V,Lim SL,Xing X,Lipovich L,Lufkin T

更新日期：2013-04-15 00:00:00

abstract：:Hippo (Hpo) signaling plays a critical role in restricting tissue growth and organ size in both invertebrate and vertebrate animals. However, how the Hpo kinase is regulated during development has not been clearly understood. Using a Bimolecular Fluorescence Complementation assay, we have investigated the functional s...

journal_title：Developmental biology

authors： Deng Y,Matsui Y,Zhang Y,Lai ZC

更新日期：2013-03-15 00:00:00

abstract：:Enhancers are flexible in terms of their location and orientation relative to the genes they regulate. However, little is known about whether the flexibility can be applied in every combination of enhancers and genes. Enhancer detection with transposable elements is a powerful method to identify enhancers in the genom...

journal_title：Developmental biology

authors： Hozumi A,Yoshida R,Horie T,Sakuma T,Yamamoto T,Sasakura Y

更新日期：2013-03-01 00:00:00

abstract：:Early mammalian embryogenesis is controlled by mechanisms governing the balance between pluripotency and differentiation. The expression of early lineage-specific genes can vary significantly between species, with implications for developmental control and stem cell derivation. However, the mechanisms involved in patt...

journal_title：Developmental biology

authors： Niakan KK,Eggan K

更新日期：2013-03-01 00:00:00

abstract：:Elk3/Net/Sap2 (here referred to as Elk3) is an Ets ternary complex transcriptional repressor known for its involvement in angiogenesis during embryonic development. Although Elk3 is expressed in various tissues, additional roles for the protein outside of vasculature development have yet to be reported. Here, we chara...

journal_title：Developmental biology

authors： Rogers CD,Phillips JL,Bronner ME

更新日期：2013-02-15 00:00:00

abstract：:Understanding the biology of somatic stem cells in self renewing tissues represents an exciting field of study, especially given the potential to harness these cells for tissue regeneration and repair in treating injury and disease. The mammalian cornea contains a population of basal epithelial stem cells involved in ...

journal_title：Developmental biology

authors： Perry KJ,Thomas AG,Henry JJ

更新日期：2013-02-15 00:00:00

abstract：:Lysine methylation of histones is associated with both transcriptionally active chromatin and with silent chromatin, depending on what residue is modified. Histone methyltransferases and demethylases ensure that histone methylations are dynamic and can vary depending on cell cycle- or developmental stage. KDM4A demeth...

journal_title：Developmental biology

authors： Crona F,Dahlberg O,Lundberg LE,Larsson J,Mannervik M

更新日期：2013-01-15 00:00:00

abstract：:It has long been hypothesized that in fishes the contents of cortical granules are involved in the hardening of egg envelope following fertilization. We previously purified the egg envelope hardening initiation factor from the exudates released from activated medaka (Oryzias latipes) eggs and tentatively termed this p...

journal_title：Developmental biology

authors： Shibata Y,Iwamatsu T,Suzuki N,Young G,Naruse K,Nagahama Y,Yoshikuni M

更新日期：2012-12-15 00:00:00

abstract：:Transcription factors (TFs) can regulate different sets of genes to determine specific cell types by means of combinatorial codes. We previously identified closely-spaced TF binding motifs located 8.2-8.5 kb 5' to the ATG of the murine Pou4f3 gene, a gene required for late hair cell (HC) differentiation and survival. ...

journal_title：Developmental biology

authors： Masuda M,Pak K,Chavez E,Ryan AF

更新日期：2012-12-01 00:00:00

abstract：:Establishment and maintenance of functional stem cells is critical for organ development and tissue homeostasis. Little is known about the mechanisms underlying stem establishment during organogenesis. Drosophila testes are among the most thoroughly characterized systems for studying stem cell behavior, with germline ...

journal_title：Developmental biology

authors： Sinden D,Badgett M,Fry J,Jones T,Palmen R,Sheng X,Simmons A,Matunis E,Wawersik M

更新日期：2012-12-01 00:00:00

abstract：:Aurora A is a mitotic kinase essential for cell proliferation. In mice, ablation of Aurora A results in mitotic arrest and pre-implantation lethality, preventing studies at later stages of development. Here we report the effects of Aurora A ablation on embryo patterning at early post-implantation stages. Inactivation ...

journal_title：Developmental biology

authors： Yoon Y,Cowley DO,Gallant J,Jones SN,Van Dyke T,Rivera-Pérez JA

更新日期：2012-11-01 00:00:00

abstract：:Morphogenesis of the vertebrate head relies on proper dorsal-ventral (D-V) patterning of neural crest cells (NCC) within the pharyngeal arches. Endothelin-1 (Edn1)-induced signaling through the endothelin-A receptor (Ednra) is crucial for cranial NCC patterning within the mandibular portion of the first pharyngeal arc...

journal_title：Developmental biology

authors： Tavares AL,Garcia EL,Kuhn K,Woods CM,Williams T,Clouthier DE

更新日期：2012-11-01 00:00:00

abstract：:In the vertebrate head, crucial parts of the sense organs and sensory ganglia develop from special regions, the cranial placodes. Despite their cellular and functional diversity, they arise from a common field of multipotent progenitors and acquire distinct identity later under the influence of local signalling. Here ...

journal_title：Developmental biology

authors： Grocott T,Tambalo M,Streit A

更新日期：2012-10-01 00:00:00

abstract：:A fundamental issue during nervous system development is how individual cells are formed from the undefined precursors. Differentiated neurons and glia, two major cell types mediating neuronal function, are acquired from immature precursors via a series of explicit controls exerted by transcription factors such as pro...

journal_title：Developmental biology

authors： Mao H,Lv Z,Ho MS

更新日期：2012-10-01 00:00:00

abstract：:During the development of locomotion circuits it is essential that motoneurons with distinct subtype identities select the correct trajectories and target muscles. In vertebrates, the generation of motoneurons and myelinating glia depends on Olig2, one of the five Olig family bHLH transcription factors. We investigate...

journal_title：Developmental biology

authors： Oyallon J,Apitz H,Miguel-Aliaga I,Timofeev K,Ferreira L,Salecker I

更新日期：2012-09-15 00:00:00

abstract：:Spermatogenesis is a complex process that requires coordinated proliferation and differentiation of male germ cells. The molecular events that dictate this process are largely unknown, but are likely to involve highly regulated transcriptional control. In this study, we investigate the contribution of chromatin associ...

journal_title：Developmental biology

authors： Pellegrino J,Castrillon DH,David G

更新日期：2012-09-15 00:00:00

abstract：:Zygote arrest (Zar) proteins are crucial for early embryonic development, but their molecular mechanism of action is unknown. The Translational Control Sequence (TCS) in the 3' untranslated region (UTR) of the maternal mRNA, Wee1, mediates translational repression in immature Xenopus oocytes and translational activati...

journal_title：Developmental biology

authors： Charlesworth A,Yamamoto TM,Cook JM,Silva KD,Kotter CV,Carter GS,Holt JW,Lavender HF,MacNicol AM,Ying Wang Y,Wilczynska A

更新日期：2012-09-15 00:00:00

abstract：:Auxin is implicated throughout plant growth and development. Although the effects of this plant hormone have been recognized for more than a century, it is only in the past two decades that light has been shed on the molecular mechanisms that regulate auxin homeostasis, signaling, transport, crosstalk with other hormo...

journal_title：Developmental biology

authors： Finet C,Jaillais Y

更新日期：2012-09-01 00:00:00

abstract：:Distinct groups of dopaminergic neurons develop at defined anatomical sites in the brain to modulate function of a large diversity of local and far-ranging circuits. However, the molecular identity as judged from transcription factor expression has not been determined for all dopaminergic groups. Here, we analyze regi...

journal_title：Developmental biology

authors： Filippi A,Jainok C,Driever W

更新日期：2012-09-01 00:00:00

abstract：:The regulation of cell cycle rate is essential for the correct timing of proliferation and differentiation during development. Changes to cell cycle rate can have profound effects on the size, shape and cell types of a developing organ. We previously identified a zebrafish mutant ceylon (cey) that has a severe reducti...

journal_title：Developmental biology

authors： Hutchinson SA,Tooke-Locke E,Wang J,Tsai S,Katz T,Trede NS

更新日期：2012-08-15 00:00:00